《Engineering》极端制造前沿学术专题研讨会

University of Technology Sydney, Australia

Jin Dayong, Academician of the Australian Academy of Engineering, Fellow of the American Society of Medical and Biological Engineering, Fellow of the Chinese Society of Optical Engineering, and Executive Director. I graduated with a PhD from Macquarie University in 2007 and became the director of the Institute of Biomedical Materials and Instruments at the University of Technology Sydney in 2015. He has successively established the Australian Biomedical Devices and Technology Conversion Center and the Portable In Vitro Diagnostic Technology Joint Research Center funded by the Chinese Australian Ministry of Science and Technology. Received the Eureka Prize in 2015, the Australian Academy of Sciences Engineering Science Award in 2017, the Australian Prime Minister's Science Award, and funding from the Australian Laureates Program in 2021. I have published over 300 papers, including more than 30 in Nature and its sub journals, and am a top 0.1% cited scholar at Elsevier globally. Our professional fields cover biophotonics, nanooptics, instrument engineering, biochips, and other areas. Currently engaged in basic and applied research such as single-molecule detection, organelle functional imaging, spatial genomics, super-resolution imaging, etc.

The core of exploring life sciences lies in revealing the structure, composition, function, and interaction processes of subcellular organelles and molecules within living cells. Similar to the way Google creates street views, the development of ultra-high resolution microscopy imaging technology, artificial intelligence algorithms, and functional molecular probes will provide important support for us to reveal subcellular structures and functions. My report will introduce our latest high-dimensional ultra-high resolution imaging technology, which utilizes deep learning to assist in organelle segmentation and achieve fast and high-throughput analysis of organelle interactions. We have also developed a series of multimodal single-molecule probes to achieve applications such as single-molecule functional sensing, organelle functional sensing, nano temperature measurement, force measurement, and functional imaging tracking. The development of new generation organelle functional imaging technology is expected to provide new opportunities for basic and applied research such as precise diagnosis and treatment of organelles, micro nano drug delivery, and discovery of new mechanisms of organelle interaction.